aamit_urs
Member • Jul 16, 2012
Regrowth of Human body Parts
Abstract: Study of Lizard DNA and their ability to regrow their tail again & as there is some human part that also regrow like hair and nails, study of the amino acids & proteins that are responsible for the growth.
The exact mechanism of how these animals can regenerate is not currently well understood. One of the most unique aspects of regeneration in urodeles that has been well documented is that they regenerate by dedifferentiating their cells at the amputation site. Dedifferentiation is a process by which specialized cells regress to a more basic entify stem cells in these organisms. This may be one of the most important facets of studying regeneration in these animals because they provide a completely different approach to tissue regeneration than that offered by stem cells. This is not to say that stem cells are not necessary to the process, however, because the cellular dedifferentiation process in urodeles is often presented as a means to locally generate pluripotent cells (perhaps stem cells or cells very similar to them). The presence of a number of nerves is also important for the regeneration process, as well as the formation of a wound epidermis over the wounded site. If a limb is denervated at the onset of the process, it will not regenerate. Nerves may be responsible for the release of growth factors or chemotactic agents necessary for the regenerative process.
The exact mechanism of how these animals can regenerate is not currently well understood. One of the most unique aspects of regeneration in urodeles that has been well documented is that they regenerate by dedifferentiating their cells at the amputation site. Dedifferentiation is a process by which specialized cells regress to a more basic entify stem cells in these organisms. This may be one of the most important facets of studying regeneration in these animals because they provide a completely different approach to tissue regeneration than that offered by stem cells. This is not to say that stem cells are not necessary to the process, however, because the cellular dedifferentiation process in urodeles is often presented as a means to locally generate pluripotent cells (perhaps stem cells or cells very similar to them). The presence of a number of nerves is also important for the regeneration process, as well as the formation of a wound epidermis over the wounded site. If a limb is denervated at the onset of the process, it will not regenerate. Nerves may be responsible for the release of growth factors or chemotactic agents necessary for the regenerative process.
