Effect of pressure difference

People with lung or heart problems, who are unable to tolerate heights above 5000 feet above MSL may find it difficult to handle the lower oxygen levels inside a plane, which is maintained at a pressure equivalent to that between 5000 to 7500feet above MSL.
Most people can handle this. On long flights this helps people quiet and rather drowsy reducing the load on the hostesses.

A more detailed analysis can be seen here:
<a href="https://en.wikipedia.org/wiki/Cabin_pressurization" target="_blank" rel="nofollow noopener noreferrer">Cabin Pressurization</a>

Even I am sure about this Sir

But if the Rate of chnge of pressure is really high That is when the aircraft moves at speed nearly above mach2 as said in the article I had a question only in that condition

Cabin pressure is independently controlled. Are you by any chance considering the physiological aspects of acceleration to reach 2 mach?
A high acceleration can cause problems for many.
Originally propeller planes were at ambient pressure. They did have pressure variation problem if they were climbing or descending too fast. Present day turbo props do have pressurized cabins.

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Sir this article made me think this

I am not sure about the effect

But I heard that the pressurising Takes a little time which is why the ascend is always slower in an aircraft we use now a days

But this seems not the case with this design

Something does not gel. The cabin is like a closed bottle. What happens outside should not normally affect the inside pressure. The rate of ascent in a commercial aircraft is dictated by fuel economy rather than other considerations.
Interesting. Let us know if more data comes up.