Binding Interactions in the Bacterial Chemotaxis Signal Transduction Pathway - Biotech Research

Here's a research paper project for BioTech Students -

The investigation of signal transduction pathways is critical to the basic understanding of cellular processes as these pathways function to regulate diverse processes in both eukaryotes and prokaryotes. This dissertation focuses on understanding some of the biochemical events that take place in the chemotaxis signal transduction pathway of bacteria. In this system, cell-surface receptor proteins regulate a histidine protein kinase, CheA, that autophosphorylates and then transfers its phosphate to an effector protein, CheY. Phospho-CheY, in turn, influences the direction of flagellar rotation. This sequence of biochemical events establishes a chain of communication that ultimately allows the chemotaxis receptor proteins to regulate the swimming pattern of the bacterial cell when it encounters gradients of attractant and repellent chemicals in its environment. The three projects presented in this dissertation sought to fill basic gaps in our current understanding of CheA and CheY function.

Read the full abstract here - <a href="https://drum.lib.umd.edu/handle/1903/8928" target="_blank" rel="noopener noreferrer">Binding Interactions in the Bacterial Chemotaxis Signal Transduction Pathway</a>